Title : Chronic hyperammonemia alters in opposite ways membrane expression of GluA1 and GluA2 AMPA receptor subunits in cerebellum. Molecular mechanisms involved.

Pub. Date : 2018 Jan

PMID : 29107806






1 Functional Relationships(s)
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1 We show that changes in GluA2 and GluA1 membrane expression in hyperammonemia would be due to enhanced NMDA receptors activation which reduces cGMP levels and phosphodiesterase 2 (PDE2) activity, resulting in increased cAMP levels. Cyclic GMP glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus