| Protein Name | glutamate ionotropic receptor AMPA type subunit 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 50592 |
| Gene Symbol | Gria1 |
| UniProt | P19490 (GRIA1_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
317
Total Number of Articles : 460 |
Description |
glutamate ionotropic receptor AMPA type subunit 1 |
| Gene Summary |
Enables several functions, including enzyme binding activity; signaling receptor binding activity; and transmitter-gated monoatomic ion channel activity. Involved in several processes, including central nervous system development; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendrite; endosome membrane; and neuronal cell body membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic active zone membrane. Used to study cocaine dependence; hyperhomocysteinemia; morphine dependence; and withdrawal disorder. Biomarker of several diseases, including alcohol use disorder; amphetamine abuse; brain disease (multiple); cocaine abuse; and drug dependence (multiple). Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 67; autosomal recessive intellectual developmental disorder 76; and epilepsy. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |