Pub. Date : 2017
PMID : 29033541
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2-STAT3 pathway. | Dexmedetomidine | Janus kinase 2 | Rattus norvegicus |
| 2 | In addition, dexmedetomidine administration inhibits phosphorylation of JAK2 and STAT3 proteins in the hippocampus of rats 2 hours after CPB. | Dexmedetomidine | Janus kinase 2 | Rattus norvegicus |
| 3 | Therefore, we speculate that the JAK2-STAT3 pathway plays an important role in the neuroprotective effects of dexmedetomidine following brain injury induced by CPB. | Dexmedetomidine | Janus kinase 2 | Rattus norvegicus |