Pub. Date : 2018 Jul
PMID : 29027195
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | TSPYL Family Regulates CYP17A1 and CYP3A4 Expression: Potential Mechanism Contributing to Abiraterone Response in Metastatic Castration-Resistant Prostate Cancer. | abiraterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
2 | Here we show that TSPYLs, especially TSPYL 1, 2, and 4, can regulate the expression of many CYP genes, including CYP17A1, a key enzyme in androgen biosynthesis, and CYP3A4, an enzyme that catalyzes the metabolism of abiraterone, a CYP17 inhibitor. | abiraterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |