PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29027195-0 2018 TSPYL Family Regulates CYP17A1 and CYP3A4 Expression: Potential Mechanism Contributing to Abiraterone Response in Metastatic Castration-Resistant Prostate Cancer. abiraterone 90-101 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 23-30 29027195-3 2018 Here we show that TSPYLs, especially TSPYL 1, 2, and 4, can regulate the expression of many CYP genes, including CYP17A1, a key enzyme in androgen biosynthesis, and CYP3A4, an enzyme that catalyzes the metabolism of abiraterone, a CYP17 inhibitor. abiraterone 216-227 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 113-120