Pub. Date : 2018 Jan
PMID : 29025907
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | As a result, SIRT6 depletion compromises the ability of leukemia cells to repair DNA double-strand breaks that, in turn, increases their sensitivity to daunorubicin and Ara-C, both in vitro and in vivo In contrast, low SIRT6 levels observed in normal CD34+ hematopoietic progenitors explain their weaker sensitivity to genotoxic stress. | Daunorubicin | sirtuin 6 | Homo sapiens |