Protein Name sirtuin 6
Organism Homo sapiens
Gene ID 51548
Gene Symbol

SIRT6

UniProt Q8N6T7 (SIR6_HUMAN), M0R1N9 (M0R1N9_HUMAN), M0QXA0 (M0QXA0_HUMAN), B4DDV3 (B4DDV3_HUMAN)
Relationships Total Number of functionally related compound(s) : 225
Total Number of Articles : 262
Description

sirtuin 6

Gene Summary

This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

synonyms
  • NAD-dependent protein deacylase sirtuin-6
  • NAD-dependent protein deacetylase sirtuin-6
  • SIR2-like protein 6
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Properties