PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29025907-5 2018 As a result, SIRT6 depletion compromises the ability of leukemia cells to repair DNA double-strand breaks that, in turn, increases their sensitivity to daunorubicin and Ara-C, both in vitro and in vivo In contrast, low SIRT6 levels observed in normal CD34+ hematopoietic progenitors explain their weaker sensitivity to genotoxic stress. Daunorubicin 152-164 sirtuin 6 Homo sapiens 13-18