Pub. Date : 2017
PMID : 28992629
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | alpha-Lipoic Acid Promotes Neurological Recovery After Ischemic Stroke by Activating the Nrf2/HO-1 Pathway to Attenuate Oxidative Damage. | Thioctic Acid | heme oxygenase 1 | Rattus norvegicus |
| 2 | Conversely, knockdown of Nrf2 or HO-1 resulted in the down-regulation of HO-1 protein and inhibited the neuroprotective effect of alpha-LA. | Thioctic Acid | heme oxygenase 1 | Rattus norvegicus |
| 3 | CONCLUSION: alpha-LA treatment is neuroprotective and promotes functional recovery after ischemic stroke by attenuating oxidative damage, which is partially mediated by the Nrf2/HO-1 pathway. | Thioctic Acid | heme oxygenase 1 | Rattus norvegicus |