Title : Prediction of Drug-Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically-Based Pharmacokinetic Modelling.

Pub. Date : 2018 Mar

PMID : 28945011






1 Functional Relationships(s)
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Compound Name
Protein Name
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1 Schisantherin A and schisandrin A, the most abundant active ingredients of Wuzhi capsule, are known to inhibit tacrolimus metabolism by inhibiting CYP3A4/5. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens