Title : CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone.

Pub. Date : 2017 Nov

PMID : 28890368






1 Functional Relationships(s)
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1 In addition, co-administration of Abi abrogated pregnenolone metabolism and resulted in a CYP17A1-independent significant increase of DHEA (13- to >100-fold) and DHT (2.5-fold) in androgen-responsive cells. Dehydroepiandrosterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens