Title : CISD2 enhances the chemosensitivity of gastric cancer through the enhancement of 5-FU-induced apoptosis and the inhibition of autophagy by AKT/mTOR pathway.

Pub. Date : 2017 Oct

PMID : 28857517






2 Functional Relationships(s)
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1 Further investigation revealed that CISD2 enhanced sensitivity to 5-FU via an increase in apoptosis and inhibition of protective autophagy through the activation of the AKT/mTOR pathway. Fluorouracil mechanistic target of rapamycin kinase Homo sapiens
2 In conclusion, CISD2 is down-regulated in gastric cancer, and its effects on the inhibition of cellular proliferation, metastatic ability, and increased chemotherapy sensitivity are mediated by antagonism to 5-FU-induced autophagy through the AKT/mTOR pathway. Fluorouracil mechanistic target of rapamycin kinase Homo sapiens