Pub. Date : 2017 Jul 25
PMID : 28743803
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCzeta. | Ceramides | angiopoietin-like 4 | Mus musculus |
| 2 | Through metabolomic profiling, we revealed that glucocorticoid treatment increased hepatic ceramide concentrations by inducing enzymes in the ceramide synthetic pathway in an Angptl4-dependent manner. | Ceramides | angiopoietin-like 4 | Mus musculus |
| 3 | Through metabolomic profiling, we revealed that glucocorticoid treatment increased hepatic ceramide concentrations by inducing enzymes in the ceramide synthetic pathway in an Angptl4-dependent manner. | Ceramides | angiopoietin-like 4 | Mus musculus |
| 4 | Angptl4 was also required for glucocorticoids to stimulate the activities of the downstream effectors of ceramide, protein phosphatase 2A (PP2A) and protein kinase Czeta (PKCzeta). | Ceramides | angiopoietin-like 4 | Mus musculus |
| 5 | Overall, our study demonstrates the key role of Angptl4 in glucocorticoid-augmented hepatic ceramide production that induces whole-body insulin resistance. | Ceramides | angiopoietin-like 4 | Mus musculus |