Title : Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing.

Pub. Date : 2017 Jun 9

PMID : 28654077






1 Functional Relationships(s)
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1 As a proof of concept, rotenone, an inhibitor of mitochondrial respiratory complex I, was used to assess the activation of the Nrf2 signaling pathway, a key regulator of the antioxidant-response-element-(ARE)-driven cellular defense mechanism against oxidative stress. Rotenone NFE2 like bZIP transcription factor 2 Homo sapiens