Title : A polymethoxyflavone mixture extracted from orange peels, mainly containing nobiletin, 3,3',4',5,6,7,8-heptamethoxyflavone and tangeretin, suppresses melanogenesis through the acidification of cell organelles, including melanosomes.

Pub. Date : 2017 Oct

PMID : 28629701






4 Functional Relationships(s)
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1 RESULTS TREATMENT: with the PMF mixture elicited the suppression of melanogenesis, the degradation of tyrosinase in lysosomes and the mislocalization of tyrosinase associated with the acidification of intracellular organelles, including melanosomes. Phenylmethylsulfonyl Fluoride tyrosinase Homo sapiens
2 RESULTS TREATMENT: with the PMF mixture elicited the suppression of melanogenesis, the degradation of tyrosinase in lysosomes and the mislocalization of tyrosinase associated with the acidification of intracellular organelles, including melanosomes. Phenylmethylsulfonyl Fluoride tyrosinase Homo sapiens
3 The neutralization of cell organelle pH by ammonium chloride restored melanogenesis and the correct localization of tyrosinase to melanosomes, which had been suppressed by the PMF mixture. Phenylmethylsulfonyl Fluoride tyrosinase Homo sapiens
4 CONCLUSION: These results suggest that the PMF mixture suppresses the localization of tyrosinase to melanosomes and consequently inhibits melanogenesis due to the acidification of cell organelles, including melanosomes. Phenylmethylsulfonyl Fluoride tyrosinase Homo sapiens