Pub. Date : 2017 Sep
PMID : 28628491
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, we found that TopBP1, which we previously showed was involved in doxorubicin resistance through upregulation of aberrant p53, was involved in calcein-AM-mediated increased doxorubicin sensitivity. | calcein AM | DNA topoisomerase II binding protein 1 | Homo sapiens |
| 2 | Calcein-AM repressed the expression of TopBP1, which resulted in reduced expression of aberrant p53 and disrupted the antiapoptotic activity mediated by the TopBP1/mutp53 pathway in NSCLC. | calcein AM | DNA topoisomerase II binding protein 1 | Homo sapiens |
| 3 | Calcein-AM repressed the expression of TopBP1, which resulted in reduced expression of aberrant p53 and disrupted the antiapoptotic activity mediated by the TopBP1/mutp53 pathway in NSCLC. | calcein AM | DNA topoisomerase II binding protein 1 | Homo sapiens |
| 4 | Together, our findings show that calcein-AM, the cell-permeable derivative of calcein, exerts significant antitumor effects in NSCLC, and can enhance the antitumor effect of doxorubicin by regulating the TopBP1/mutp53 pathway. | calcein AM | DNA topoisomerase II binding protein 1 | Homo sapiens |