Title : Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling.

Pub. Date : 2017 Aug 11

PMID : 28539361






5 Functional Relationships(s)
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1 Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in beta-adrenoceptor signaling. NAADP CD38 antigen Mus musculus
2 CD38, which belongs to the ADP-ribosyl cyclase family, catalyzes synthesis of both NAADP and cADPR in vitro However, it remains unclear whether this is the main enzyme for their production under physiological conditions. NAADP CD38 antigen Mus musculus
3 Membrane permeabilization of cardiac myocytes with saponin and/or Triton X-100 increased NAADP synthesis, indicating that intracellular CD38 contributes to NAADP production. NAADP CD38 antigen Mus musculus
4 Membrane permeabilization of cardiac myocytes with saponin and/or Triton X-100 increased NAADP synthesis, indicating that intracellular CD38 contributes to NAADP production. NAADP CD38 antigen Mus musculus
5 These observations support generation of NAADP and cADPR by intracellular CD38, which contributes to effects of beta-adrenoreceptor stimulation to increase both Ca2+ transients and the tendency to disturb heart rhythm. NAADP CD38 antigen Mus musculus