PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28539361-0 2017 Synthesis of the Ca2+-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in beta-adrenoceptor signaling. NAADP 44-49 CD38 antigen Mus musculus 77-81 28539361-2 2017 CD38, which belongs to the ADP-ribosyl cyclase family, catalyzes synthesis of both NAADP and cADPR in vitro However, it remains unclear whether this is the main enzyme for their production under physiological conditions. NAADP 83-88 CD38 antigen Mus musculus 0-4 28539361-4 2017 Membrane permeabilization of cardiac myocytes with saponin and/or Triton X-100 increased NAADP synthesis, indicating that intracellular CD38 contributes to NAADP production. NAADP 89-94 CD38 antigen Mus musculus 136-140 28539361-4 2017 Membrane permeabilization of cardiac myocytes with saponin and/or Triton X-100 increased NAADP synthesis, indicating that intracellular CD38 contributes to NAADP production. NAADP 156-161 CD38 antigen Mus musculus 136-140 28539361-11 2017 These observations support generation of NAADP and cADPR by intracellular CD38, which contributes to effects of beta-adrenoreceptor stimulation to increase both Ca2+ transients and the tendency to disturb heart rhythm. NAADP 41-46 CD38 antigen Mus musculus 74-78