PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28530704-0	2017	Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma.	Dehydroepiandrosterone	98-102	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	16-23	
28530704-2	2017	Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for prostate cancer progression and acquired chemotherapeutic resistance.	Dehydroepiandrosterone	63-85	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	0-20	
28530704-2	2017	Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for prostate cancer progression and acquired chemotherapeutic resistance.	Dehydroepiandrosterone	63-85	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	22-29	
28530704-2	2017	Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for prostate cancer progression and acquired chemotherapeutic resistance.	Dehydroepiandrosterone	87-91	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	0-20	
28530704-2	2017	Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for prostate cancer progression and acquired chemotherapeutic resistance.	Dehydroepiandrosterone	87-91	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	22-29	
28530704-3	2017	However, whether CYP17A1-mediated DHEA synthesis is involved in brain tumor malignancy, especially in glioma, the most prevalent brain tumor, is unknown.	Dehydroepiandrosterone	34-38	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	17-24	
28530704-4	2017	To investigate the role of CYP17A1 in glioma, we determined that CYP17A1 expression is significantly increased in gliomas, which secrete more DHEA than normal astrocytes.	Dehydroepiandrosterone	142-146	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	65-72	
28530704-9	2017	Together, our results suggest that components of the Sp1-CYP17A1-DHEA axis, which promotes the development of TMZ resistance, may serve as potential biomarkers and therapeutic targets in recurrent glioma.	Dehydroepiandrosterone	65-69	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	57-64