Title : Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma.

Pub. Date : 2017 May 22

PMID : 28530704






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for prostate cancer progression and acquired chemotherapeutic resistance. Pregnenolone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for prostate cancer progression and acquired chemotherapeutic resistance. Pregnenolone cytochrome P450 family 17 subfamily A member 1 Homo sapiens