Pub. Date : 2017 Aug
PMID : 28528971
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulatory effects of 4-methoxychalcone on adipocyte differentiation through PPARgamma activation and reverse effect on TNF-alpha in 3T3-L1 cells. | 4'-methoxychalcone | peroxisome proliferator activated receptor gamma | Mus musculus |
| 2 | Additionally, treatment with 4-MC significantly increased the PPARgamma-induced transcriptional activity and 4-MC also enhanced the DNA binding affinity of PPARgamma to the proliferator-activated receptor response elements (PPRE) at target promoters. | 4'-methoxychalcone | peroxisome proliferator activated receptor gamma | Mus musculus |
| 3 | Additionally, treatment with 4-MC significantly increased the PPARgamma-induced transcriptional activity and 4-MC also enhanced the DNA binding affinity of PPARgamma to the proliferator-activated receptor response elements (PPRE) at target promoters. | 4'-methoxychalcone | peroxisome proliferator activated receptor gamma | Mus musculus |
| 4 | Additionally, treatment with 4-MC significantly increased the PPARgamma-induced transcriptional activity and 4-MC also enhanced the DNA binding affinity of PPARgamma to the proliferator-activated receptor response elements (PPRE) at target promoters. | 4'-methoxychalcone | peroxisome proliferator activated receptor gamma | Mus musculus |
| 5 | Treatment with 4-MC enhanced the lipid accumulation and strongly up-regulated the expression of adipogenic markers, including PPARgamma, aP2, FAS, and adiponectin during adipocyte differentiation. | 4'-methoxychalcone | peroxisome proliferator activated receptor gamma | Mus musculus |
| 6 | This study clearly demonstrates that 4-MC enhanced adipocyte differentiation, in part, by its potent effects on PPARgamma activation and by its reverse effect on TNF-alpha. | 4'-methoxychalcone | peroxisome proliferator activated receptor gamma | Mus musculus |