| Protein Name | peroxisome proliferator activated receptor gamma |
|---|---|
| Organism | Mus musculus |
| Gene ID | 19016 |
| Gene Symbol | Pparg |
| UniProt | P37238 (PPARG_MOUSE), Q6GU14 (Q6GU14_MOUSE), M1VPI1 (M1VPI1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
1556
Total Number of Articles : 3119 |
Description |
peroxisome proliferator activated receptor gamma |
| Gene Summary |
This gene encodes a nuclear receptor protein belonging to the peroxisome proliferator-activated receptor (Ppar) family. The encoded protein is a ligand-activated transcription factor that is involved in the regulation of adipocyte differentiation and glucose homeostasis. The encoded protein forms a heterodimer with retinoid X receptors and binds to DNA motifs termed "peroxisome proliferator response elements" to either activate or inhibit gene expression. Mice lacking the encoded protein die at an embryonic stage due to severe defects in placental vascularization. When the embryos lacking this gene are supplemented with healthy placentas, the mutants survive to term, but succumb to lipodystrophy and multiple hemorrhages. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] |
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