Title : Hydroxy-Substituted Heteroarylpiperazines: Novel Scaffolds for β-Arrestin-Biased D2R Agonists.

Pub. Date : 2017 Jun 8

PMID : 28489379






1 Functional Relationships(s)
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1 In contrast to the weak agonistic behavior of aripiprazole, these ligands are capable of effectively mimicking those interactions of dopamine and the D2R that are crucial for an active state, leading to the recruitment of beta-arrestin-2. Dopamine arrestin beta 2 Homo sapiens