| Protein Name | arrestin beta 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 409 |
| Gene Symbol | ARRB2 |
| UniProt | P32121 (ARRB2_HUMAN), Q68DZ5 (Q68DZ5_HUMAN), K7ENA6 (K7ENA6_HUMAN), Q59EM5 (Q59EM5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
221
Total Number of Articles : 223 |
Description |
arrestin beta 2 |
| Gene Summary |
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] |
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