Title : Losartan, a selective antagonist of AT1 receptor, attenuates seawater inhalation induced lung injury via modulating JAK2/STATs and apoptosis in rat.

Pub. Date : 2017 Aug

PMID : 28483563






4 Functional Relationships(s)
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1 Losartan, a selective antagonist of AT1 receptor, attenuates seawater inhalation induced lung injury via modulating JAK2/STATs and apoptosis in rat. Losartan angiotensin II receptor, type 1a Rattus norvegicus
2 Losartan is a selective antagonist of AngI type (AT1) receptor of Angiotensin II (Ang II), which is widely used as a clinical medicine for the hypertension. Losartan angiotensin II receptor, type 1a Rattus norvegicus
3 The aim of this research was to clarify whether Ang II participated in the inflammatory response of ALI induced by seawater inhalation, and whether losartan had the protective effects on ALI by blocking the combination of Ang II and AT1 receptor. Losartan angiotensin II receptor, type 1a Rattus norvegicus
4 While pretreatment of losartan (especially 15 mg/kg and 30 mg/kg) alleviated lung injury by inhibiting Ang-II and AT1 receptor combination and in turn decreased the expression of p-NF-kappaB and activation of JAK2/STATs pathway. Losartan angiotensin II receptor, type 1a Rattus norvegicus