Protein Name angiotensin II receptor, type 1a
Organism Rattus norvegicus
Gene ID 24180
Gene Symbol

Agtr1a

UniProt P25095 (AGTRA_RAT)
Relationships Total Number of functionally related compound(s) : 596
Total Number of Articles : 1447
Description

angiotensin II receptor, type 1a

Gene Summary

Enables D1 dopamine receptor binding activity; angiotensin type I receptor activity; and protein kinase binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cation homeostasis; and response to glucocorticoid. Located in several cellular components, including basolateral plasma membrane; organelle outer membrane; and recycling endosome. Used to study several diseases, including asthma; chronic kidney disease; congestive heart failure; hypertension (multiple); and nephritis. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; artery disease (multiple); glomerulosclerosis (multiple); hyperinsulinism; and placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; COVID-19; artery disease (multiple); chronic kidney disease; and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • type-1 angiotensin II receptor A
  • AT1 receptor A
  • angiotensin II type-1 receptor A
Click to show/hide the synonyms
Properties