Title : Efflux Transporters Regulate Arsenite-Induced Genotoxicity in Double Negative and Double Positive T Cells.

Pub. Date : 2017 Jul 1

PMID : 28472378






5 Functional Relationships(s)
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1 Induction of Mdr1 (Abcb1) and Mrp1 (Abcc1), 2 multidrug resistance transporters and exporters of As+3, was associated with the reversal of As+3-induced double strand breaks and DNA damage. as+3 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus
2 Induction of Mdr1 (Abcb1) and Mrp1 (Abcc1), 2 multidrug resistance transporters and exporters of As+3, was associated with the reversal of As+3-induced double strand breaks and DNA damage. as+3 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus
3 Induction of Mdr1 (Abcb1) and Mrp1 (Abcc1), 2 multidrug resistance transporters and exporters of As+3, was associated with the reversal of As+3-induced double strand breaks and DNA damage. as+3 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus
4 Induction of Mdr1 (Abcb1) and Mrp1 (Abcc1), 2 multidrug resistance transporters and exporters of As+3, was associated with the reversal of As+3-induced double strand breaks and DNA damage. as+3 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus
5 Knockdown study of As+3 exporters in the DN thymic cell line, D1 using siRNA, demonstrated that Mdr1 and Mrp1 regulate intracellular As+3 accumulation and genotoxicity. as+3 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus