Protein Name ATP-binding cassette, sub-family C member 1
Organism Mus musculus
Gene ID 17250
Gene Symbol

Abcc1

UniProt O35379 (MRP1_MOUSE), A5D6P3 (A5D6P3_MOUSE)
Relationships Total Number of functionally related compound(s) : 211
Total Number of Articles : 193
Description

ATP-binding cassette, sub-family C member 1

Gene Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011]

synonyms
  • multidrug resistance-associated protein 1
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 1
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 1a
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Properties