Pub. Date : 2017 Apr
PMID : 28413517
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isoflurane anesthesia induces liver injury by regulating the expression of insulin-like growth factor 1. | Isoflurane | insulin-like growth factor 1 | Rattus norvegicus |
| 2 | Compared with the control group, levels of IGF-1 and IGF-1R mRNA and protein were significantly decreased following exposure to isoflurane (all P<0.05). | Isoflurane | insulin-like growth factor 1 | Rattus norvegicus |
| 3 | The necrosis rate and liver apoptosis were significantly increased in the group treated with isoflurane alone compared with the control group (P<0.05), but were significantly decreased compared with the isoflurane group following application of IGF-1 (P<0.05). | Isoflurane | insulin-like growth factor 1 | Rattus norvegicus |
| 4 | The necrosis rate and liver apoptosis were significantly increased in the group treated with isoflurane alone compared with the control group (P<0.05), but were significantly decreased compared with the isoflurane group following application of IGF-1 (P<0.05). | Isoflurane | insulin-like growth factor 1 | Rattus norvegicus |
| 5 | The present study therefore suggests that isoflurane induces liver injury in part by regulating the expression of IGF-1 and that application of IGF-1 may protect against liver injury induced by isoflurane exposure. | Isoflurane | insulin-like growth factor 1 | Rattus norvegicus |
| 6 | The present study therefore suggests that isoflurane induces liver injury in part by regulating the expression of IGF-1 and that application of IGF-1 may protect against liver injury induced by isoflurane exposure. | Isoflurane | insulin-like growth factor 1 | Rattus norvegicus |