| Protein Name | insulin-like growth factor 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24482 |
| Gene Symbol | Igf1 |
| UniProt | P08025 (IGF1_RAT), Q5RK13 (Q5RK13_RAT), F8WFZ5 (F8WFZ5_RAT), Q63261 (Q63261_RAT), A0A0G2JX40 (A0A0G2JX40_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
1018
Total Number of Articles : 2117 |
Description |
insulin-like growth factor 1 |
| Gene Summary |
Enables protein serine/threonine kinase activator activity; signaling receptor binding activity; and steroid binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of cell death; and positive regulation of cell differentiation. Located in several cellular components, including interstitial matrix; neuronal cell body; and platelet alpha granule. Used to study brain ischemia; diabetic neuropathy; and hypertension. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); congenital diaphragmatic hernia; folic acid deficiency anemia; and hypothyroidism (multiple). Human ortholog(s) of this gene implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1). [provided by Alliance of Genome Resources, Apr 2022] |
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| Properties | |