PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28413517-0	2017	Isoflurane anesthesia induces liver injury by regulating the expression of insulin-like growth factor 1.	Isoflurane	0-10	insulin-like growth factor 1	Rattus norvegicus	75-103	
28413517-8	2017	Compared with the control group, levels of IGF-1 and IGF-1R mRNA and protein were significantly decreased following exposure to isoflurane (all P<0.05).	Isoflurane	128-138	insulin-like growth factor 1	Rattus norvegicus	43-48	
28413517-9	2017	The necrosis rate and liver apoptosis were significantly increased in the group treated with isoflurane alone compared with the control group (P<0.05), but were significantly decreased compared with the isoflurane group following application of IGF-1 (P<0.05).	Isoflurane	93-103	insulin-like growth factor 1	Rattus norvegicus	248-253	
28413517-9	2017	The necrosis rate and liver apoptosis were significantly increased in the group treated with isoflurane alone compared with the control group (P<0.05), but were significantly decreased compared with the isoflurane group following application of IGF-1 (P<0.05).	Isoflurane	206-216	insulin-like growth factor 1	Rattus norvegicus	248-253	
28413517-12	2017	The present study therefore suggests that isoflurane induces liver injury in part by regulating the expression of IGF-1 and that application of IGF-1 may protect against liver injury induced by isoflurane exposure.	Isoflurane	42-52	insulin-like growth factor 1	Rattus norvegicus	114-119	
28413517-12	2017	The present study therefore suggests that isoflurane induces liver injury in part by regulating the expression of IGF-1 and that application of IGF-1 may protect against liver injury induced by isoflurane exposure.	Isoflurane	194-204	insulin-like growth factor 1	Rattus norvegicus	144-149