Pub. Date : 2017 Jun
PMID : 28384415
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Downregulation of cytochrome P450 2C8 by 3-methylcholanthrene in human hepatocellular carcinoma cell lines. | Methylcholanthrene | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 2 | MC suppresses mRNA levels for CYP2C8, an important human P450, in cultured human hepatocytes. | Methylcholanthrene | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 3 | To avoid hepatocyte lot-to-lot variability, we assessed CYP2C8 regulation by MC in HepaRG cells, a terminally differentiated human hepatocellular carcinoma cell line that maintains high P450 expression. | Methylcholanthrene | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 4 | MC strongly induced CYP1A1 mRNA levels and markedly downregulated CYP2C8 mRNA levels in HepaRG cells. | Methylcholanthrene | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
| 5 | Although MC also suppressed CYP2C8 mRNA levels in the HepG2 human hepatocellular carcinoma cell line, basal CYP2C8 expression was extremely low. | Methylcholanthrene | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |