PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28384415-0	2017	Downregulation of cytochrome P450 2C8 by 3-methylcholanthrene in human hepatocellular carcinoma cell lines.	Methylcholanthrene	41-61	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	18-37	
28384415-3	2017	MC suppresses mRNA levels for CYP2C8, an important human P450, in cultured human hepatocytes.	Methylcholanthrene	0-2	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	30-36	
28384415-4	2017	To avoid hepatocyte lot-to-lot variability, we assessed CYP2C8 regulation by MC in HepaRG cells, a terminally differentiated human hepatocellular carcinoma cell line that maintains high P450 expression.	Methylcholanthrene	77-79	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	56-62	
28384415-5	2017	MC strongly induced CYP1A1 mRNA levels and markedly downregulated CYP2C8 mRNA levels in HepaRG cells.	Methylcholanthrene	0-2	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	66-72	
28384415-6	2017	Although MC also suppressed CYP2C8 mRNA levels in the HepG2 human hepatocellular carcinoma cell line, basal CYP2C8 expression was extremely low.	Methylcholanthrene	9-11	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	28-34