Title : Resveratrol mitigates lipopolysaccharide-mediated acute inflammation in rats by inhibiting the TLR4/NF-κBp65/MAPKs signaling cascade.

Pub. Date : 2017 Mar 21

PMID : 28322346






2 Functional Relationships(s)
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1 RSV could inhibit the signaling cascades of NF-kappaBp65 and MAPKs through down-regulating the mRNA levels of IkappaBalpha, p38MAPK, JNK, ERK1, ERK2 and ERK5 in liver and lung, and suppressing the dynamic changes of proteins and phosphorylated proteins including IkappaBalpha, NF-kappaBp65, p38MAPK, JNK, ERK1/2 and ERK5 from tissue"s cytoplasm to nucleus. Resveratrol mitogen-activated protein kinase 8 Rattus norvegicus
2 RSV could inhibit the signaling cascades of NF-kappaBp65 and MAPKs through down-regulating the mRNA levels of IkappaBalpha, p38MAPK, JNK, ERK1, ERK2 and ERK5 in liver and lung, and suppressing the dynamic changes of proteins and phosphorylated proteins including IkappaBalpha, NF-kappaBp65, p38MAPK, JNK, ERK1/2 and ERK5 from tissue"s cytoplasm to nucleus. Resveratrol mitogen-activated protein kinase 8 Rattus norvegicus