Title : A novel class of apical sodium--dependent bile salt transporter inhibitors: 1-(2,4-bifluorophenyl)-7-dialkylamino-1,8-naphthyridine-3-carboxamides.

Pub. Date : 2017 Mar

PMID : 28303230






2 Functional Relationships(s)
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1 Inhibition of ASBT could increase the excretion of bile acids, thus increasing bile acid synthesis and consequently cholesterol consumption. Cholesterol solute carrier family 10 member 2 Homo sapiens
2 Therefore, ASBT is an attractive target for developing new cholesterol-lowering drugs. Cholesterol solute carrier family 10 member 2 Homo sapiens