Protein Name solute carrier family 10 member 2
Organism Homo sapiens
Gene ID 6555
Gene Symbol

SLC10A2

UniProt Q12908 (NTCP2_HUMAN)
Relationships Total Number of functionally related compound(s) : 177
Total Number of Articles : 186
Description

solute carrier family 10 member 2

Gene Summary

This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010]

synonyms
  • ileal sodium/bile acid cotransporter
  • Na(+)-dependent ileal bile acid transporter
  • Na+/taurocholate cotransporting polypeptide 2
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Properties