Pub. Date : 2017 Apr
PMID : 28260081
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2. | Sevoflurane | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 2 | Furthermore, we found that nuclear factor E2-related factor 2 (Nrf2), an activator of the stress response, was upregulated and activated upon sevoflurane treatment both in the rat hippocampus and in H4 cells. | Sevoflurane | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 3 | In addition, minocycline further augmented the upregulation and activation of Nrf2 when used in conjunction with sevoflurane. | Sevoflurane | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 4 | On the whole, our findings indicate that minocycline may exert protective effects against sevoflurane-induced cell injury via the Nrf2-modulated antioxidant response and the inhibition of the activation of the NF-kappaB signaling pathway. | Sevoflurane | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |