PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28260081-0 2017 Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2. Sevoflurane 23-34 NFE2 like bZIP transcription factor 2 Rattus norvegicus 73-77 28260081-6 2017 Furthermore, we found that nuclear factor E2-related factor 2 (Nrf2), an activator of the stress response, was upregulated and activated upon sevoflurane treatment both in the rat hippocampus and in H4 cells. Sevoflurane 142-153 NFE2 like bZIP transcription factor 2 Rattus norvegicus 63-67 28260081-7 2017 In addition, minocycline further augmented the upregulation and activation of Nrf2 when used in conjunction with sevoflurane. Sevoflurane 113-124 NFE2 like bZIP transcription factor 2 Rattus norvegicus 78-82 28260081-9 2017 On the whole, our findings indicate that minocycline may exert protective effects against sevoflurane-induced cell injury via the Nrf2-modulated antioxidant response and the inhibition of the activation of the NF-kappaB signaling pathway. Sevoflurane 90-101 NFE2 like bZIP transcription factor 2 Rattus norvegicus 130-134