Pub. Date : 2017 Apr 1
PMID : 28237700
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin E1 reduces the keratinocyte toxicity of sorafenib by maintaining signal transducer and activator of transcription 3 (STAT3) activity and enhancing the cAMP response element binding protein (CREB) activity. | Sorafenib | cAMP responsive element binding protein 1 | Homo sapiens |
| 2 | Prostaglandin E1 reduces the keratinocyte toxicity of sorafenib by maintaining signal transducer and activator of transcription 3 (STAT3) activity and enhancing the cAMP response element binding protein (CREB) activity. | Sorafenib | cAMP responsive element binding protein 1 | Homo sapiens |
| 3 | Collectively, these findings indicate that PGE1 blocks the inhibitory effects of sorafenib on cell growth by maintaining the activity of STAT3 and enhancing the CREB activity. | Sorafenib | cAMP responsive element binding protein 1 | Homo sapiens |