PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28237700-0	2017	Prostaglandin E1 reduces the keratinocyte toxicity of sorafenib by maintaining signal transducer and activator of transcription 3 (STAT3) activity and enhancing the cAMP response element binding protein (CREB) activity.	Sorafenib	54-63	cAMP responsive element binding protein 1	Homo sapiens	165-202	
28237700-0	2017	Prostaglandin E1 reduces the keratinocyte toxicity of sorafenib by maintaining signal transducer and activator of transcription 3 (STAT3) activity and enhancing the cAMP response element binding protein (CREB) activity.	Sorafenib	54-63	cAMP responsive element binding protein 1	Homo sapiens	204-208	
28237700-10	2017	Collectively, these findings indicate that PGE1 blocks the inhibitory effects of sorafenib on cell growth by maintaining the activity of STAT3 and enhancing the CREB activity.	Sorafenib	81-90	cAMP responsive element binding protein 1	Homo sapiens	161-165