Pub. Date : 1987 Jul 1
PMID : 2822018
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PLC activation by thrombin was dependent on GTP, and was completely inhibited by a 15-fold excess of the non-hydrolysable GDP analogue guanosine 5"-[beta-thio]diphosphate (GDP[S]). | Guanosine Triphosphate | coagulation factor II, thrombin | Homo sapiens |
| 2 | It is concluded that an early post-receptor effect of thrombin is the activation of a Ca2+- and GTP-dependent membrane-associated PLC that specifically cleaves PIP2 and PIP. | Guanosine Triphosphate | coagulation factor II, thrombin | Homo sapiens |
| 3 | This result suggests that the cell-surface receptor for thrombin is coupled to a polyphosphoinositide-specific PLC by a GTP-binding protein that regulates PLC activity by increasing its sensitivity to Ca2+. | Guanosine Triphosphate | coagulation factor II, thrombin | Homo sapiens |