Pub. Date : 2017 Jun
PMID : 28217977
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | miR-506 enhances the sensitivity of human colorectal cancer cells to oxaliplatin by suppressing MDR1/P-gp expression. | Oxaliplatin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | CONCLUSION: Taken together, the findings of our study demonstrate that miR-506 overexpression in HCT116-OxR cells enhances oxaliplatin sensitivity by inhibiting MDR1/P-gp expression via down-regulation of the Wnt/beta-catenin pathway and thus provide a rationale for the development of miRNA-based strategies to reverse oxaliplatin resistance in CRC cells. | Oxaliplatin | ATP binding cassette subfamily B member 1 | Homo sapiens |