Title : Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1β and IL-18 and Arrests CKD.

Pub. Date : 2017 May

PMID : 27881606






1 Functional Relationships(s)
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1 Damaged mitochondria release danger molecules, such as reactive oxygen species, DNA, and cardiolipin, which can cause NLRP3 inflammasome activation and upregulation of IL-18 and IL-1beta It is not known if mitochondrial damage persists long after ischemia to sustain chronic inflammasome activation. Reactive Oxygen Species NLR family, pyrin domain containing 3 Rattus norvegicus