Protein Name NLR family, pyrin domain containing 3
Organism Rattus norvegicus
Gene ID 287362
Gene Symbol

Nlrp3

UniProt D4A523 (NLRP3_RAT)
Relationships Total Number of functionally related compound(s) : 604
Total Number of Articles : 811
Description

NLR family, pyrin domain containing 3

Gene Summary

Predicted to enable DNA-binding transcription factor binding activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in leukocyte migration involved in inflammatory response; response to ethanol; and response to organic cyclic compound. Predicted to be located in Golgi membrane and nucleus. Predicted to be part of NLRP3 inflammasome complex. Biomarker of alcoholic hepatitis. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • NACHT, LRR and PYD domains-containing protein 3
  • PYRIN-containing APAF1-like protein 1
  • cold autoinflammatory syndrome 1 homolog
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Properties