Protein Name NLR family, pyrin domain containing 3
Organism Rattus norvegicus
Gene ID 287362
Gene Symbol

Nlrp3

UniProt D4A523 (NLRP3_RAT)
Relationships Total Number of functionally related compound(s) : 604
Total Number of Articles : 811
Description

NLR family, pyrin domain containing 3

Gene Summary

Predicted to enable several functions, including ATP hydrolysis activity; adenyl ribonucleotide binding activity; and cysteine-type endopeptidase activator activity. Involved in response to ethanol. Predicted to be located in several cellular components, including Golgi membrane; interphase microtubule organizing center; and mitochondrion. Predicted to be part of NLRP3 inflammasome complex. Predicted to be active in cytosol and membrane. Biomarker of alcoholic hepatitis and myocardial infarction. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • NACHT, LRR and PYD domains-containing protein 3
  • PYRIN-containing APAF1-like protein 1
  • cold autoinflammatory syndrome 1 homolog
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Properties