Title : Clarithromycin, Midazolam, and Digoxin: Application of PBPK Modeling to Gain New Insights into Drug-Drug Interactions and Co-medication Regimens.

Pub. Date : 2017 Jan

PMID : 27822600






1 Functional Relationships(s)
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1 During co-treatment with 250 or 500 mg clarithromycin (bid), the midazolam and digoxin doses should be reduced by 74 to 88% and by 21 to 22%, respectively, to ensure constant midazolam and digoxin exposures (AUC). Midazolam BH3 interacting domain death agonist Homo sapiens