Pub. Date : 2016 Nov 9
PMID : 27713966
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hydroxysafflor yellow A inhibits IL-1beta-induced release of IL-6, IL-8, and MMP-1 via suppression of ERK, NF-kappaB and AP-1 signaling in SW982 human synovial cells. | hydroxysafflor yellow A | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | HSYA also inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), p65 and c-Jun. | hydroxysafflor yellow A | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | HSYA also inhibited the phosphorylation of extracellular signal-regulated kinase (ERK), p65 and c-Jun. | hydroxysafflor yellow A | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | These results indicate that the inhibitory effects of HSYA on IL-1beta-induced IL-6, IL-8 and MMP-1 release might be mediated via suppression of ERK, nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) signaling pathways. | hydroxysafflor yellow A | mitogen-activated protein kinase 1 | Homo sapiens |