Pub. Date : 2017 Jun
PMID : 27615060
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Evaluation of the rotenone-induced activation of the Nrf2 pathway in a neuronal model derived from human induced pluripotent stem cells. | Rotenone | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Therefore, in the current study, we evaluated whether Nrf2 signaling machinery is expressed in human induced pluripotent stem cells (hiPSCs)-derived mixed neuronal/glial culture and if so whether it becomes activated by rotenone-induced oxidative stress mediated by complex I inhibition of mitochondrial respiration. | Rotenone | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Rotenone was found to induce the activation of Nrf2 signaling particularly at the highest tested concentration (100 nM), as shown by Nrf2 nuclear translocation and the up-regulation of the Nrf2-downstream antioxidant enzymes, NQO1 and SRXN1. | Rotenone | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | Rotenone was found to induce the activation of Nrf2 signaling particularly at the highest tested concentration (100 nM), as shown by Nrf2 nuclear translocation and the up-regulation of the Nrf2-downstream antioxidant enzymes, NQO1 and SRXN1. | Rotenone | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 5 | Rotenone was found to induce the activation of Nrf2 signaling particularly at the highest tested concentration (100 nM), as shown by Nrf2 nuclear translocation and the up-regulation of the Nrf2-downstream antioxidant enzymes, NQO1 and SRXN1. | Rotenone | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 6 | Interestingly, exposure to rotenone also increased the number of astroglial cells in which Nrf2 activation may play an important role in neuroprotection. | Rotenone | NFE2 like bZIP transcription factor 2 | Homo sapiens |