Title : Differential protein stability of EGFR mutants determines responsiveness to tyrosine kinase inhibitors.

Pub. Date : 2016 Oct 18

PMID : 27612423






1 Functional Relationships(s)
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1 Erlotinib treatment induced polyubiquitination and proteasomal degradation, primarily in a c-CBL-independent manner, in TKI sensitive L858R and delE746-A750 mutants when compared to the L858R/T790M mutant, which correlated with drug sensitivity. Erlotinib Hydrochloride Cbl proto-oncogene Homo sapiens