Title : Dehydroevodiamine•HCl Protects Against Memory Impairment and Cerebral Amyloid-β Production in Tg2576 Mice by Acting as a β-Secretase Inhibitor.

Pub. Date : 2016

PMID : 27577574






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 To investigate the preventive action of DHED in Alzheimer"s disease (AD), a progressive neurodegenerative disorder characterized by memory decline, amyloid-beta (Abeta) protein-containing neuritic plaques and neurofibrillary tangles, in this study, we proposed that DHED may be therapeutically effective against the memory impairment and disease-related neurochemical changes that occur in Tg2576 (Tg) mice. 3,16-dihydroxyandrost-5-ene-17,19-dione amyloid beta (A4) precursor protein Mus musculus
2 Additionally, we investigated whether DHED may be a beta-secretase inhibitor that affects the production of Abeta related to the formation of neuritic plaques. 3,16-dihydroxyandrost-5-ene-17,19-dione amyloid beta (A4) precursor protein Mus musculus
3 In conclusion, DHED may exhibit therapeutic effects for AD as a beta-secretase inhibitor. 3,16-dihydroxyandrost-5-ene-17,19-dione amyloid beta (A4) precursor protein Mus musculus