PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27577574-2 2016 To investigate the preventive action of DHED in Alzheimer"s disease (AD), a progressive neurodegenerative disorder characterized by memory decline, amyloid-beta (Abeta) protein-containing neuritic plaques and neurofibrillary tangles, in this study, we proposed that DHED may be therapeutically effective against the memory impairment and disease-related neurochemical changes that occur in Tg2576 (Tg) mice. 3,16-dihydroxyandrost-5-ene-17,19-dione 40-44 amyloid beta (A4) precursor protein Mus musculus 148-168 27577574-6 2016 Additionally, we investigated whether DHED may be a beta-secretase inhibitor that affects the production of Abeta related to the formation of neuritic plaques. 3,16-dihydroxyandrost-5-ene-17,19-dione 38-42 amyloid beta (A4) precursor protein Mus musculus 50-56 27577574-10 2016 In conclusion, DHED may exhibit therapeutic effects for AD as a beta-secretase inhibitor. 3,16-dihydroxyandrost-5-ene-17,19-dione 15-19 amyloid beta (A4) precursor protein Mus musculus 62-68